Endocrine Abstracts

The GH-receptor antagonist PEG, used as monotherapy or in combination to SA, has been demonstrated to normalize IGF1 levels in up to 90% of acromegalic patients after unsuccessful surgery and/or radiotherapy and resistant to conventional SA treatment. The aim of this study is to evaluate the efficacy and safety of combined treatment with SA plus PEG in a cohort of acromegalic patients resistant to conventional SA therapy. Thirty-two acromegalic patients (17 M, 15 F, age 39.6&#...

Cushing’s disease (CD) is very rare in prepubertal children, and remains a challenge to diagnose and manage. We review the diagnostic features and therapeutic outcome of prepubertal (defined as testicular volume <4 ml (M) and breast stage <2 (F)) CD patients treated in a single centre. Fifteen prepubertal patients (median age 9.4 years; range 5.8–13.7) fulfilled standard diagnostic criteria for CD and there was male preponderance (12 M (80%), median age 9.1 y...

Context: An increased mortality by cancer is reported in grafted patients.Objective: This multicentric study aimed to investigate whether the prognosis of thyroid cancer was modified by transplantationResults: Sixty nine patients (35 M/34 F; median age 41 years) with a history of both thyroid cancer and transplantation were recruited via specialized networks (TUTHYREF and DIVAT). Evolution and outcome were retrospectively analyzed ...

It is well established that oestrogens participate in the control of normal spermatogenesis and endogenous or environmental oestrogens are involved in pathological germ cell proliferation including testicular germ cell tumours. The effects of oestrogen are now known to be mediated by oestrogen receptor-α (ERα) and ERβ subtypes, but only ERβ has been found in human germ cells of normal testis. However, its expression was markedly diminished in seminomas, emb...

Central obesity and insulin resistance are more prevalent in women with PCOS, affecting both normal weight and obese subjects. The metabolic effects of insulin are partially dependent on the amount of lean mass and insulin resistance seems to selectively affect the metabolic, but not the mitogenic, actions of insulin. Therefore, this age-matched case-control study assessed total and segmental lean muscle mass in classic or ovulatory polycystic ovary syndrome (PCOS) patients an...

Introduction: Pituitary somatotrop adenomas are very rare in children and adolescents. They are supposed to be more invasive (invasion of cavernous sinuses or meninges±compression of adjacent neural structures) than adults’ones. We aimed to analyze their characteristics, and their complications.Patients and subjects: are studied subjects whose clinical symptoms began before 20 years old. They all had biological, hormonal, ophthalmological, radi...

Corticotropin-releasing hormone (CRH) is known to be produced and secreted by normal rat corticotropes and to contribute in a paracrine manner to POMC synthesis and ACTH secretion in these cells. The regulation of intrapituitary CRH however still has to be clarified.Aim: This study was to establish whether CRH gene expression can be measured in rat pituitaries in vitro and whether CRH modulates its own gene expression within the pitu...

Introduction: CyberKnife (CK), an innovative LINAC-based robotic device for frameless stereotactic surgery, is an emerging approach in the management of tumours of the sellar region.Patients and methods: In total, 14 patients (six men, mean age 52.7 years) with sellar tumours (three craniopharyngiomas and 11 pituitary adenomas) were evaluated. Pituitary adenomas (PA) were non-functioning (7), GH-secreting (2), one GH/TSH-secreting (1) or PRL-secreting (1...

There are considerable variations in diagnosis and therapeutical practices in hyperthyroidism (HT) between countries. Few of these differences rely on a scientific basis. we present the results of a study conducted among a representative sample of 263 French endocrinologists. All consecutive patients seen for HT during the study period were included. Symptoms, biological data and treatment were recorded. 1214 patients with hyperthyroidism were included, 1144 had an identified ...

Introduction: Hashimoto’s thyroiditis can be accompanied by thyroid cancer. It is reported that there is an association between selenium deficiency and thyroid cancer. In addition, it is known that chronic inflammation is another causal factor in the etiology of cancer.In this study, we aimed to determine whether selenium or oxidative stress is a modifying factor for the association between Hashimoto’s thyroiditis and cancer.<p class="abste...